Clinical utility of intravenous immunoglobulins in autoimmune diseases
نویسنده
چکیده
Durante los últimos años, la utilización de las inmunoglobulinas endovenosas (Ig ev) se ha extendido desde las inmunodeficiencias primarias, a una serie de entidades clínicas como los procesos infecciosos, las enfermedades neurológicas inflamatorias y las enfermedades autoinmunes. Las Ig ev son una terapia bien tolerada, con pocos efectos adversos, aunque con un elevado coste económico. Aunque el número de ensayos cínicos aleatorizados es escaso, se ha demostrado su eficacia en entidades autoinmunitarias como las enfermedades autoinmunes ampollosas, la dermatomiositis, el lupus eritematoso sistémico y ciertas vasculitis refractarias al tratamiento inmunodepresor habitual. En otras enfermedades como el síndrome de Sjögren, la esclerosis sistémica, el síndrome antifosfolipídico, la artritis reumatoide o la miopatía con cuerpos de inclusión, su utilidad aún es controvertida.
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